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Tumor Immunology and Cancer Vaccines J. Koerting 4Rückschlüsse16It all started with an observation. Edward Jenner, an English physician, observed that milkmaids who contracted cowpox were rarely victims of smallpox epidemic, a disease that in? icted a heavy toll on humankind with an estimate of 500 million victimsworldwide. In1796,Jennerinoculatedtheextracted? uidfromblistersonthe handofamilkmaidwhowasinfectedwithcowpoxintothearman8yearoldpeasant boy. After the boy recovered from a mild illness caused by this